In 2K22, those defenders don't seem to 2K22 MT crash as often and you can play a a pick-and-roll game that feels more like an NBA game. Now, it's all about being aware of the defense and making the right decision. If you request your center to make a choice and his man switches to you, toss it over to the big man and let him take on the smaller player. If they don't swap and you're left with an open space. Get to the bucket and hit a layup or get fouled.
To begin a roll-and-pick, hold down L1 (LB on Xbox) as you point to any player you would like to bring for the pick. The key here is to take your time. If you are unable to find the switch but don't see the lane, don't push it. Reset and try again. Remember, you must take your time and play slow and smart.
This is especially true for those who are looking to dive into NBA 2K22 during this year. If you're interested in playing MyTeam, MyCareer, or MyWNBA, you probably need make a decision and stick to the game. However, you aren't able to explore different modes, but all three come with a season pass with content to unlock. It seems a bit easier to finish out the season pass than in the past, but should you spread yourself too thin, you could not receive all of the benefits.
However, if you're an amateur player don't worry about it. All three modes have plenty of options and moving between them isn't a problem unless you really want to compete other players.
If you're already a top quality MyTeam athlete, this suggestion won't work for you. You likely already have the skills needed to 2K22 mt buy play in online. However, for newer players (or those who are in need of refresher), playing offline modes such as Triple Threat Offline and Domination will do two, very beneficial things.